The mitochondrial DNA makeup of Romanians: A forensic mtDNA control region database and phylogenetic characterization

Turchi C, Stanciu F, Paselli G, Buscemi L, Parson W, Tagliabracci A. Forensic Sci Int t. 2016 Sep;24:136-142. doi: 10.1016/j.fsigen.2016.06.013. Epub 2016 Jun 30. PMID: 27414754.

Abstract:

To evaluate the pattern of Romanian population from a perspective and to establish an appropriate , we rated a high-quality control region dataset from 407 Romanian subjects belonging to four major historical regions: Moldavia, , Wallachia and Dobruja. The entire control region (CR) was analyzed by Sanger-type assays and the resulting 306 different haplotypes were classified into s according to the most updated phylogeny. The Romanian pool is mainly composed of West Eurasian lineages H (31.7%), U (12.8%), J (10.8%), R (10.1%), T (9.1%), N (8.1%), HV (5.4%),K (3.7%), HV0 (4.2%), with exceptions of East Asian M (3.4%) and African L (0.7%).

The pattern of variation observed in this study indicates that the pool is geographically homoous across Romania and that the composition reveals signals of admixture of populations of different origin. The PCA scatterplot supported this scenario, with Romania located in southeastern Europe area, close to Bulgaria and Hungary, and as a borderland with respect to east Mediterranean and other eastern European countries.

High haplotype diversity (0.993) and nucleotide diversity indices (0.00838 ` 0.00426), together with low random match probability (0.0087) suggest the usefulness of this control region dataset as a in routine forensic analysis and in the investigation of maternal tic lineages in the Romanian population.

Keywords: , , ,

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